Cover Feature: Photoinducible Oncometabolite Detection (ChemBioChem 3/2019)

Cover Picture: Detection of mRNA in Mammalian Cells with a Split Ribozyme Reporter (ChemBioChem 6/2006)

The cover picture shows a split RNA reporter strategy for detecting target mRNA in mammalian cells. A tetrahymena group I intron ribozyme reporter is split into two halves, each of which carries a part of the coding sequence of the reporter mRNA, a fragment of the ribozyme, and an antisense sequence complementary to a target mRNA. Both halves bind with the target mRNA and are assembled into an ...

Cover Feature Outlook

Cover Feature Physiological Computing

Brain−computer interfaces (BCIs) hold great promise for improving information delivery and preserving user attention, but this promise has not yet translated to practical use. A prototype BCI that optimizes email notifications in noisy, complex environments, CARSON combines multiple measures from the brain to predict both cognitive workload and message relevancy to determine the optimum time to...

Cover Feature Software Engineering

Cover Feature Big Data

Today’s applications often contain datasets that are too big to fit in a single computer’s main memory. Analyzing these massive datasets will require scalable and sophisticated machine-learning methods. Two commonly used approaches are stochastic optimization and inference algorithms,1 which process one data point at a time; and distributed computing based on the MapReduce framework,2 where the...